Detalhe da pesquisa
1.
Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound.
Proc Natl Acad Sci U S A
; 120(28): e2219543120, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37406092
2.
Neutral sphingomyelinase 2 is required for HIV-1 maturation.
Proc Natl Acad Sci U S A
; 120(28): e2219475120, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37406093
3.
Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility.
Mol Psychiatry
; 2024 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38615102
4.
SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation.
J Immunol
; 211(12): 1767-1782, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37947442
5.
Neuronal deletion of nSMase2 reduces the production of Aß and directly protects neurons.
Neurobiol Dis
; 177: 105987, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36603748
6.
Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders.
Mol Psychiatry
; 27(10): 4252-4263, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35732693
7.
Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV.
Neurobiol Dis
; 169: 105734, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35462006
8.
Regulatory T cells reduce endothelial neutral sphingomyelinase 2 to prevent T-cell migration into tumors.
Eur J Immunol
; 51(9): 2317-2329, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34272885
9.
Model studies towards prodrugs of the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) containing a diazo precursor.
Bioorg Med Chem Lett
; 50: 128321, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34400301
10.
MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.
Proc Natl Acad Sci U S A
; 115(51): E12024-E12033, 2018 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30514812
11.
Looking for Drugs in All the Wrong Places: Use of GCPII Inhibitors Outside the Brain.
Neurochem Res
; 45(6): 1256-1267, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-31749072
12.
Targeting Mitochondria in Tumor-Associated Macrophages using a Dendrimer-Conjugated TSPO Ligand that Stimulates Antitumor Signaling in Glioblastoma.
Biomacromolecules
; 21(9): 3909-3922, 2020 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786523
13.
Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker.
Bioorg Med Chem
; 28(20): 115698, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33069080
14.
DCC-related developmental effects of abused- versus therapeutic-like amphetamine doses in adolescence.
Addict Biol
; 25(4): e12791, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31192517
15.
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
Proteomics
; 19(21-22): e1800451, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31231915
16.
Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs.
Mol Pharm
; 16(10): 4292-4301, 2019 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31503493
17.
Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors.
Bioorg Med Chem
; 27(2): 255-264, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30552009
18.
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.
Proc Natl Acad Sci U S A
; 113(36): E5328-36, 2016 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27559084
19.
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Nephrol Dial Transplant
; 33(8): 1343-1353, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420817
20.
Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination.
J Neurosci
; 36(34): 8783-9, 2016 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27559162